Impact of extrapyramidal signs on dementia severity and progression in
neuropathology confirmed Alzheimer Disease and Dementia With Lewy Bodies 
   Lead Investigator:    Jagan Pillai
   Institution      :    Cleveland Clinic
   E-Mail           :    pillaij@ccf.org
   Proposal ID      :    675



   Proposal Description:
   1. Characterize the extra pyramidal signs during longitudinal follow up in a neuropathology confirmed cohort of Alzheimer disease and Lewy Body Dementia. 2. Study relationship between the nature and severity of extra pyramidal signs and severity of dementia (MMSE, CDR-Sum of boxes and CDR-Global) in the same cohort. Determine the interaction between severity of Lewy body pathology, Alzheimer pathology and vascular pathology in relation to severity of UPDRS motor score and extra pyramidal symptoms. Linear regression models will be used to assess differences between diagnostic groups in UPDRS total scores. The model will be adjusted for age, sex, education, exposure to smoking and medications that could impact extrapyramidal symptoms and severity of pathological stage. Secondary analyses will compare the prevalence of each extrapyramidal symptom across the diagnostic group, severity of pathology stage and severity of dementia (by MMSE CDR).